Medication Safety for Parkinson
Antipsychotics
Safe Medications
Pimavanserin (Nuplazid, FDA approved to treat Parkinson’s disease psychosis)
Quetiapine (Seroquel)
Clozapine (Clozaril)
Medications to Avoid
Avoid all other typical and atypical antipsychotics
Nausea/ GI drugs
Safe Medications
Domperidone (Motilium)
Trimethobenzamide (Tigan)
Ondansetron (Zofran)
Dolasetron (Anzemet)
Granisetron (Kytril)
Medications to Avoid
Prochlormethazine (Compazine)
Metoclopramide (Reglan)
Promethazine (Phenergan)
Droperidol (Inapsine)
Anti Depressants
Safe Medications
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Citalopram (Celexa)
Escitalopram (Lexapro)
Venlafaxine (Effexor)
Medications to Avoid
Amoxapine (Asendin)
Anesthesia
Safe Medications
Request a consult with the anesthesiologist, surgeon and Parkinson’s doctor to determine best anesthesia given your Parkinson’s symptoms and medications
Medications to Avoid
If patient is taking MAO-B inhibitor such as Selegiline or Rasagiline (Azilect), avoid:
Meperidine (Demerol)
Tramadol (Rybix, Ryzolt, Ultram)
Droperidol (Inapsine)
Methadone (Dolophine, Methadose)
Propoxyphene (Darvon, PP-Cap)
Cyclobenzaprine (Amrix, Fexmid, Flexeril)
Halothane (Fluothane)
Pain Medications
Safe Medications
Most are safe to use, but narcotic medications may cause confusion/ psychosis and constipation
Medications to Avoid
If patient is taking MAO-B inhibitor such as selegiline or rasagiline (Azilect), avoid meperidine (Demerol)
Reference: Parkinson Foundation Website, available at: www.parkinson.org